Guided anatomical manipulation for endoscopic procedures

ABSTRACT

Various embodiments of the present disclosure encompass manipulative endoscopic guidance device employing an endoscopic viewing controller ( 20 ) for controlling a display of an endoscopic view ( 11 ) of an anatomical structure, and a manipulative guidance controller ( 30 ) for controlling a display of one or more guided manipulation anchors ( 50 - 52 ) within the display of the endoscopic view ( 11 ) of the anatomical structure. A guided manipulation anchor ( 50 - 52 ) is representative of a location marking and/or a motion directive of a guided manipulation of the anatomical structure (e.g., grasping, pulling, pushing, sliding, reorienting, tilting, removing, or repositioning of the anatomical structure). The manipulative guidance controller ( 30 ) may generate an anchor by analyzing a correlation of the endoscopic view ( 11 ) of the anatomical structure with a knowledge base of image(s), model(s) and/or details corresponding to the anatomical structure and by deriving the anchor based on a degree of correlation of the endoscopic view ( 11 ) of the anatomical structure with the knowledge base.

FIELD OF THE INVENTION

The present disclosure generally relates to image guided endoscopic based diagnostic procedures, therapeutic procedures and surgical procedures. The present disclosure specifically relates to a guided manipulation of an anatomical structure within an endoscopic view.

BACKGROUND OF THE INVENTION

In minimally invasive surgery, a surgeon views the tissue under treatment using a camera that extends into the patient's body. These cameras are called endoscopes and a particular type of endoscope being utilized is dependent on the procedure being performed (e.g., anoscopy, arthroscopy, bronchoscopy, colonoscopy, colposcopy, cystoscopy, esophagoscopy, gastroscopy, laparoscopy, laryngoscopy, neuroendoscopy, proctoscopy, sigmoidoscopy and thoracoscopy).

During the surgery, the surgeon performs visual inspection and exploration of the subject anatomical region via an endoscope prior to the primary surgical tasks to thereby gain familiarity with the patient's anatomy and identify important anatomical structures (e.g., known blood vessels and nerves). In doing so, the surgeon familiarizes themselves with the patient's tissue, which the surgeon had not seen hitherto. Endoscopy has traditionally been used in this manner as a passive visualization tool.

Depending on the procedure, the surgeon may attempt to relate what he/she has seen with what they know from preoperative information, including anatomical imaging as well as experience and textbook anatomical knowledge. However, tissues seen under the endoscopic view is often not immediately recognizable by the surgeon, because the field of view is limited to a small area that is difficult to contextualize in isolation. While preoperative planning may be used to determine the best course of surgical action, as the intervention begins, there may not be enough information revealed to fully combine the preoperative information to endoscopy. Then as the intervention proceeds, any information fusion already obtained may be rendered invalid by tissue deformation, physiological motion, patient motion, and so on. For the intervention to reference a plan, endoscope views must be continuously analyzed and updated to evolving surgical conditions.

More particularly, a visual appearance of a particular patient's anatomy is unknown until surgery time, because preoperative information via scans (e.g., X-ray, computed-tomography (CT), positron-emission tomography (PET), etc.) primarily show differences in attenuation of tissue to radiation energy, which delineate structures such as tumors, vessels, and airways. A preliminary activity in minimally invasive endoscopic surgery is thus gaining familiarity with the tissue appearance. During this exploratory phase, the surgeon views tissue through the endoscope while performing manipulations using tools, and simultaneously dissecting tissue to expose anatomical structures while identifying landmarks to facilitate the primary surgical task. For example, in tumor resection, the surgeon attempts to identify blood vessels and other structures in the proximity of the tumor, in order to avoid damaging them during resection.

This exploration phase is a time consuming, uncertain, and unquantifiable activity that makes many aspects of surgical procedures difficult to reproduce. An existing approach fuses preoperative information (e.g., an X-ray scan, a CT scan, a PET scan, etc.) into the endoscopic view. In practice, however, the image fusion approach largely fails due to extreme tissue deformation, difficult depth visualization, and artifacts of imaging (e.g., specularities, occlusions, shadows, small field of view, motion blur, and focus blur).

SUMMARY OF THE INVENTION

The present disclosure describes a novel, unique controller generation of preferred guided manipulations of an anatomical structure (e.g., tissue, bone, nerves and blood vessels) that are communicated to a surgeon during an endoscopic procedure. Examples of such guided manipulations include, but are not limited to a grasping, a pulling, a pushing, a sliding, a reorienting, a tilting, a dissecting, a bending, a twisting, a flexing, an extending, a compressing, a removing and/or a repositioning of an anatomical structure during an endoscopic based diagnostic procedure, an endoscopic based therapeutic procedure and/or an endoscopic based surgical procedure. A clinician (e.g., a radiologist, a therapist or a surgeon) may manually or robotically implement the guided manipulation, or a controller may automatically control robotic instruments to manipulate the tissue accordingly.

The present disclosure may be embodied as (1) a manipulative guidance controller, (2) a manipulative endoscopic guidance device incorporating the manipulative guidance controller, (3) a manipulative endoscopic guidance system incorporating the manipulative endoscopic guidance device, (4) a manipulative endoscopic guidance method utilizing the manipulative guidance controller, (5) a manipulative endoscopic guidance method utilizing the manipulative endoscopic guidance device and (6) a manipulative endoscopic guidance method utilizing the manipulative endoscopic guidance system.

Various manipulative guidance controller embodiments of the present disclosure encompass a manipulative guidance controller for controlling a display of one or more guided manipulation anchors within a display of an endoscopic view of an anatomical structure. A guided manipulation anchor is representative of a location marking and/or a motion directive of a guided manipulation of the anatomical structure including, but not limited to, a grasping, a pulling, a pushing, a sliding, a reorienting, a tilting, a removing, and/or a repositioning of the anatomical structure during an endoscopic based diagnostic procedure, an endoscopic based therapeutic procedure and/or an endoscopic based surgical procedure.

A clinician (e.g., a radiologist, a therapist or a surgeon) may manually or robotically implement the guided manipulation as displayed, or the manipulative guidance controller may automatically control robotic instruments to manipulate the tissue accordingly.

The manipulative guidance controller may generate a guided manipulation anchor (1) by analyzing a correlation of the endoscopic view of the anatomical structure with a knowledge base of image(s), model(s) and/or detail(s) corresponding to the anatomical structure and (2) by deriving the guided manipulation anchor based on a degree of correlation of the endoscopic view of the anatomical structure with the knowledge base.

The manipulative guidance controller may receive the endoscopic view of the anatomical structure or may ascertain the endoscopic view of the anatomical structure from a tracked positioning of an endoscope relative to a partial or whole volume scan of an anatomical structure.

Various manipulative endoscopic guidance device embodiments encompass the manipulative guidance controller and an endoscopic viewing controller for controlling the display of the endoscopic view of the anatomical structure. Examples of an endoscopic viewing controller include, but are not limited to, controllers for implementing endoscopic based diagnostic, therapeutic and/or surgical guidance of tools and instruments within an anatomical region as known in the art of the present disclosure and hereinafter conceived.

Various manipulative endoscopic guidance system embodiments encompass the manipulative endoscopic guidance device and an endoscope as known in the art of the present disclosure and hereinafter conceived for generating the endoscopic view of the anatomical structure. Examples of the endoscope include, but are not limited to, an anoscope, an arthroscope, a bronchoscope, a colonoscope, a colposcope, a cystoscope, an esophagoscope, a gastroscope, a laparoscope, a laryngoscope, a neuroendoscope, a proctoscope, a sigmoidoscope and a thoracoscope.

Various manipulative endoscopic guidance method embodiments of the present disclosure encompass the manipulative guidance controller receiving an endoscopic view of an anatomical structure, and the manipulative endoscopic guidance controlling a display of one or more guided manipulation anchors within a display of the endoscopic view of the anatomical structure. Again, a guided manipulation anchor is representative of a location marking and/or a motion directive of a guided manipulation of the anatomical structure including, but not limited to a grasping, a pulling, a pushing, a sliding, a reorienting, a tilting, a removing, and/or a repositioning of the anatomical structure during a diagnostic procedure, a therapeutic procedure and/or a surgical procedure.

A clinician (e.g., a radiologist, a therapist or a surgeon) may manually or robotically implement the guided manipulation as displayed, or the manipulative guidance controller may automatically control robotic instruments to manipulate the tissue accordingly.

The method may involve the manipulative guidance controller generating a guided manipulation anchor (1) by analyzing a correlation of the endoscopic view of the anatomical structure with a knowledge base of image(s), model(s) and/or detail(s) corresponding to the anatomical structure and (2) by deriving the guided manipulation anchor based on a degree of correlation of the endoscopic view of the anatomical structure with the knowledge base.

The manipulative guidance controller may receive the endoscopic view of the anatomical structure or may ascertain the endoscopic view of the anatomical structure from a tracked positioning of an endoscope relative to a partial or whole volume scan of an anatomical structure.

The manipulative endoscopic guidance method may further involve an endoscope generating the endoscopic view of the anatomical structure and/or an endoscopic viewing controller controlling the display of the endoscopic view of the anatomical structure.

The foregoing embodiments and other embodiments of the present disclosure as well as various structures and advantages of the present disclosure will become further apparent from the following detailed description of various embodiments of the present disclosure read in conjunction with the accompanying drawings. The detailed description and drawings are merely illustrative of the present disclosure rather than limiting, the scope of the present disclosure being defined by the appended claims and equivalents thereof.

BRIEF DESCRIPTION OF THE DRAWINGS

The present disclosure will present in detail the following description of exemplary embodiments with reference to the following figures wherein:

FIG. 1 illustrates an exemplary embodiment of a manipulative endoscopic guidance device in accordance with the present disclosure;

FIGS. 2A-2C illustrate exemplary embodiments of the manipulative endoscopic guidance device of FIG. 1 in accordance with the present disclosure; FIG. 3 illustrates an exemplary embodiment of a manipulative guidance method in accordance with the present disclosure executable by the manipulative endoscopic guidance device of FIGS. 1A-1C;

FIG. 4 illustrates an exemplary embodiment of a manipulative endoscopic guidance system in accordance with the present disclosure incorporating the manipulative endoscopic guidance device of FIG. 1 ;

FIG. 5 illustrates an exemplary embodiment of a manipulative guidance controller in accordance with the present disclosure; and

FIG. 6 illustrates a flowchart representative of an exemplary embodiment of a manipulative guidance method in accordance with the present disclosure executable by the manipulative guidance controller of FIG. 4 .

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

The present disclosure is applicable to numerous and various diagnostic, therapeutic and surgical procedures utilizing an endoscope including, but not limited to, anoscopy, arthroscopy, bronchoscopy, colonoscopy, colposcopy, cystoscopy, esophagoscopy, gastroscopy, laparoscopy, laryngoscopy, neuroendoscopy, proctoscopy, sigmoidoscopy and thoracoscopy.

The present disclosure improves upon the prior art of endoscopic procedures by providing guided manipulations for a clinician (e.g., a radiologist, a therapist or a surgeon) on how to manually or robotically manipulate anatomical structure(s) (e.g., tissue, bone, nerves and blood vessels) in an endoscopic view of the anatomical structure(s) that may (1) reveal hidden anatomical structure(s) within the endoscopic view and/or (2) reposition and/or reorient anatomical structures(s) within the endoscopic view to facilitate a diagnostic analysis, a therapeutic treatment and/or a surgical operation of the anatomical structure(s) within the endoscopic view.

For purposes of describing and claiming the present disclosure, the term “guided manipulation” broadly encompasses, as known in the art of the present disclosure and hereinafter conceived, a delineated contact of a tool/instrument with an anatomical structure for purposes of altering, reshaping, distorting, transforming or otherwise manipulating a configuration, a position and/or an orientation of the anatomical structure within an endoscopic view of the anatomical structure.

Examples of guided manipulations include, but are not limited to, a grasping, a pulling, a pushing, a sliding, a tilting, a dissecting, a bending, a twisting, a flexing, an extending, a compressing and/or removing of an anatomical structure during an endoscopic procedure.

One objective of the guided manipulation may be a manipulation of an anatomical structure within the endoscopic view into a more known, baseline, or recognizable state to the clinician for facilitating a diagnostic analysis, a therapeutic treatment and/or a surgical operation of the anatomical structure.

Another objective of a guided manipulation may be an exposure of additional anatomical structure(s) hidden within the endoscopic view for facilitating a diagnostic analysis, a therapeutic treatment and/or a surgical operation of the additional anatomical structure(s) within the endoscopic view.

Additionally, there are a variety of uses of a guided manipulation of the present disclosure. Examples of such uses include, but are not limited to, (1) an exposure of oblique facing tissue to the endoscope to facilitate a better understanding of the endoscopic view, (2) a combining of endoscopic views to stitch larger pictures of a corresponding anatomical region (e.g., a thorax region, an abdomen region, etc.), (3) an ability to restore views that are no longer within a field of view of the endoscope or that have been hidden behind other objects, and (4) a use of force sensing to apply known amounts of force to anatomical structure(s).

For purposes of describing and claiming the present disclosure, the term “anchor” broadly encompasses a visual representation, as known in the art of the present disclosure and hereinafter conceived, for continually marking a specific location within view of an imaging modality, and the term “guided manipulation anchor” broadly encompasses a visual representation, in accordance with the present disclosure, of a location marking and/or a motion directive of a guided manipulation within an endoscopic view of an anatomical structure whereby a clinician (e.g., a radiologist, a therapist or a surgeon) may manually or robotically implement the guided manipulation of the anatomical structure(s), or a controller may automatically control robotic instruments to manipulate the anatomical structure(s) accordingly.

In practice, a guided manipulation anchor of the present disclosure may be overlaid on an endoscopic video feed whereby the anchor is a static visual augmentation on any type of physical, virtual or augmented display (e.g., display monitors, head mounted displays, etc.). Additionally, the display may render a 3D model of the scene if such data is available. A guided manipulation anchor of the present disclosure may also be dynamic whereby the guided manipulation anchor appears to adhere to the associated anatomical structure (e.g., tissue, bone, nerves and blood vessels).

For example, if a grasp location is on the outer edge of an organ, the anchor overlay that tells a surgeon to grasp there may track with the underlying tissue as it moves. Consequently, the anchor overlay may disappear if the tissue goes out of the view or becomes hidden, and reappear with the connected tissue. Guided manipulation anchor may be put on tools/instruments as well to communicate how tools/instruments should be moved.

Further in practice, visually, a guided manipulation anchor of the present disclosure may be opaque to grab the clinician's attention, or translucent to allow vision by the clinician to the anatomical structure(s) behind the guided manipulation anchor. Guided manipulation anchors of the present disclosure may also vary by the nature of the anchors (e.g., informative or query within a context of the diagnostic, therapeutic and/or surgical endoscopic procedure). The shapes, colors, and sizes of a guided manipulation anchors of the present disclosure may be similarly adjusted to communicate messages. For examples, a shape of a guided manipulation anchor of the present disclosure may be oriented to communicate a directionality of anatomical manipulation and/or may be animated to show motion suggestions.

Also in practice, guided manipulation anchors of the present disclosure may be communicated through means beyond visualization. For example, a haptic display maybe shaped or colored or a haptic joystick may be vibrated to communicate to the clinician that the instrument location is at a grasp point near tissue. Other nonlimiting communication means include audible cues and combinations of haptic stimuli.

Additionally, in practice, directionality of anatomical manipulation may be determined based on a combination of how the anatomical structure is oriented in the endoscopic view and the immediate task(s) to be performed during the endoscopic procedure. For example, if tissue to be grasped is an edge of an organ, then a direction should be into the organ for a folding motion and outward for a stretching motion. An embodiment of determining tissue characteristics may involve torsion motion of the tissue grasp as well to thereby allow for an execution of a desired motion in a preferred direction of tissue.

More particularly, a direction of anatomical manipulation may be computed based on efficient task execution and workflow as well. For example, if it is known that a particular incision is most safely and efficiently performed at a certain angle, then a clinician may be guided on staging the tissue to that angle. Also a direction of anatomical manipulation may be computed based on intraoperative criteria such as, for example, current angulation of tissue, camera, and instruments, which also may be extended to one or more sequences of tasks.

To facilitate an understanding of the present disclosure, the following description of FIGS. 1-2C teaches respective exemplary embodiments of a manipulative endoscopic guidance device in accordance with the present disclosure. From the description of FIGS. 1-2C, those having ordinary skill in the art of the present disclosure will appreciate how to apply the present disclosure to make and use additional embodiments of manipulative endoscopic guidance devices in accordance with the present disclosure.

Referring to FIG. 1 , an endoscope 10 is an endoscope as known in the art of the present disclosure or hereinafter conceived for generating an endoscopic view of the anatomical structure, such as, for example, an endoscopic view 11 of a lung as shown in FIG. 1 . Examples of the endoscope include, but are not limited to, an anoscope, an arthroscope, a bronchoscope, a colonoscope, a colposcope, a cystoscope, an esophagoscope, a gastroscope, a laparoscope, a laryngoscope, a neuroendoscope, a proctoscope, a sigmoidoscope and a thoracoscope.

The present disclosure provides a manipulative endoscopic guidance device employing an endoscopic viewing controller 20 and a manipulate guidance controller 30.

For purposes of describing and claiming the present disclosure, the term “endoscopic viewing controller” encompasses all structural configurations, as understood in the art of the present disclosure and as exemplary described in the present disclosure, of a main circuit board or an integrated circuit for controlling an application of various principles of the present disclosure for controlling a display of the endoscopic view of an anatomical structure as known in the art of present disclosure or hereinafter conceived. The structural configuration of the endoscopic viewing controller may include, but is not limited to, processor(s), computer-usable/computer readable storage medium(s), an operating system, application module(s), peripheral device controller(s), slot(s) and port(s).

For purposes of describing and claiming the present disclosure, the term “application module” as related to an endoscopic viewing controller broadly encompasses an application incorporated within or accessible by an endoscopic viewing controller consisting of an electronic circuit (e.g., electronic components and/or hardware) and/or an executable program (e.g., executable software stored on non-transitory computer readable medium(s) and/or firmware) for executing a specific application associated for controlling a display of the endoscopic view of an anatomical structure as known in the art of present disclosure or hereinafter conceived.

Examples of an endoscopic viewing controller 20 include, but are not limited to, endoscopic viewing controllers for implementing endoscopic based diagnostic, therapeutic and/or surgical guidance of tools and instruments within an anatomical region as known in the art of the present disclosure and hereinafter conceived.

Still referring to FIG. 1 , for purposes of describing and claiming the present disclosure, the term “manipulative guidance controller” encompasses all structural configurations, as understood in the art of the present disclosure and as exemplary described in the present disclosure, of a main circuit board or an integrated circuit for applying various principles of the present disclosure for controlling a display of one or more guided manipulation anchors within a display of an endoscopic view of an anatomical structure in accordance with the present disclosure. The structural configuration of the manipulative guidance controller may include, but is not limited to, processor(s), computer-usable/computer readable storage medium(s), an operating system, application module(s), peripheral device controller(s), slot(s) and port(s).

For purposes of describing and claiming the present disclosure, the term “application module” as related to a manipulative guidance controller broadly encompasses an application incorporated within or accessible by a manipulative guidance controller consisting of an electronic circuit (e.g., electronic components and/or hardware) and/or an executable program (e.g., executable software stored on non-transitory computer readable medium(s) and/or firmware) for executing a specific application associated controlling a display of one or more guided manipulation anchors within a display of an endoscopic view of an anatomical structure in accordance with the present disclosure.

As previously described herein, a guided manipulation anchor is representative of a location marking and/or a motion directive of a guided manipulation of the anatomical structure including, but not limited to, a grasping, a pulling, a pushing, a sliding, a reorienting, a tilting, a removing, and/or a repositioning of the anatomical structure during an endoscopic based diagnostic procedure, an endoscopic based therapeutic procedure and/or an endoscopic based surgical procedure. A clinician (e.g., a radiologist, a therapist or a surgeon) may manually or robotically implement the guided manipulation as displayed, or the manipulative guidance controller may automatically control robotic instruments to manipulate the tissue accordingly.

For example, a guided manipulation anchor 50 as overlaid on endoscopic view 11 of a lung is representative of a location marking of a guided manipulation of the anatomical structure whereby a shape, a color and/or a size of guided manipulation anchor 50 may expressly communicate a particular type of guided manipulation of the anatomical structure (e.g., a grasping, a pulling, a pushing, a sliding, a reorienting, a tilting, a removing, and/or a repositioning of the anatomical structure).

By further example, a guided manipulation anchor 51 as overlaid on endoscopic view 11 of a lung is representative of a motion directive of a guided manipulation of the anatomical structure whereby a shape, a color and/or a size of guided manipulation anchor 50 may expressly communicate a particular type of guided manipulation of the anatomical structure (e.g., a grasping, a pulling, a pushing, a sliding, a reorienting, a tilting, a removing, and/or a repositioning of the anatomical structure).

By further example, a guided manipulation anchor 52 as overlaid on endoscopic view 11 of a lung is representative of a location marking and a motion directive of a guided manipulation of the anatomical structure whereby a shape, a color and/or a size of guided manipulation anchor 50 may expressly communicate a particular type of guided manipulation of the anatomical structure (e.g., a grasping, a pulling, a pushing, a sliding, a reorienting, a tilting, a removing, and/or a repositioning of the anatomical structure).

Still referring to FIG. 1 , in practice, manipulative guidance controller 30 generates a guided manipulation anchor in dependence of the endoscopic view of the anatomical structure in a context of the endoscopic based diagnostic procedure, an endoscopic based therapeutic procedure and/or an endoscopic based surgical procedure.

In one embodiment as will be further described in the present disclosure, manipulative guidance controller 30 may generate a guided manipulation anchor (1) by analyzing a correlation of the endoscopic view of the anatomical structure with a knowledge base of image(s), model(s) and/or detail(s) corresponding to an anatomical structure and (2) by deriving the guided manipulation anchor based on a degree of correlation of the endoscopic view of the anatomical structure with the knowledge base.

For purposes of describing and claims the present disclosure, the term “correlation” broadly encompasses an endoscopic view having a mutual relationship with a target view of an anatomical structure. Examples of a mutual relationship includes, but is not limited to, (1) an image matching of the endoscopic view to the target view within a volume scan of the anatomical structure, (2) an imaging matching of the endoscopic view to a target view on a model of the anatomical structure, (3) an imaging matching of the endoscopic view to a target view of an image compilation of anatomical structure, (4) an imaging matching of anatomical features illustrated within the endoscopic view to with salient anatomical features illustrated within the target view, and (5) an evolving image matching of the endoscopic view to the target view as treatment tasks and/or surgical tasks are performed on the anatomical structure.

In practice, a target view of the anatomical structure may be a view delineated during a planning phase of an endoscopic procedure or identified by a clinician during the navigation phase of the endoscopic procedure.

Also in practice, a degree of correlation dictates whether a single guided manipulation anchor or a single set of guided manipulation anchors are needed for representing location marking(s) and motion directive(s) of guided manipulation(s) of the anatomical structure, or whether a temporal series of guided manipulation anchors are needed for representing a temporal series of location markings and motion directive of guided manipulations of the anatomical structure.

Still referring to FIG. 1 , the manipulative guidance controller may receive the endoscopic view of the anatomical structure or may ascertain the endoscopic view of the anatomical structure from a tracked positioning of an endoscope relative to a partial or whole volume scan of an anatomical structure.

Examples of images corresponding to the endoscopic based procedure include, but are not limited to, volumetric scans, pre-operative or intra-operative, of an anatomical region (e.g., a CT scan, a MRI scan, a PET scan, a 3D ultrasound scan, a 3D X-ray scan).

Examples of models corresponding to the endoscopic based procedure include, but are not limited to, three-dimensional representations of an anatomical structure (e.g., anatomical models generated via subtractive or additive manufacturing in accordance with an anatomical atlas).

Examples of detail(s) corresponding to the anatomical structure include but are not limited to, biological properties of the anatomical structure and endoscopic procedural steps associated with the anatomical structure.

Still referring to FIG. 1 , in practice, endoscopic viewing controller 20 and manipulative guidance controller 30 may be segregated as shown, partially integrated or wholly integrated.

In a first exemplary embodiment as shown in FIG. 2A, an endoscopic viewing controller 20 a generates an endoscopic view 11 a of an anatomical structure from an endoscope 10 a as known in the art of the present disclosure. Endoscopic viewing controller 20 a employs a guidance planner 21 for generating a planned view of the anatomical structure via a volume scan of an anatomical region as known in the art of the present disclosure or hereinafter conceived, and an image guide 22 for controlling a display of endoscopic view 11 a of an anatomical structure on a monitor 70 via a display controller 60 a as known in the art of the present disclosure or hereinafter conceived. The display of endoscopic view 11 a may be adjacent to or overlaid upon a display of the volume scan of the anatomical region.

A manipulative guidance controller 30 a receives endoscopic view 11 a of the anatomical structure from endoscopic viewing controller 20 a as shown or alternatively ascertains endoscopic view 11 a of the anatomical structure from a tracking of endoscope 10 a relative to the volume scan of the anatomical region. Manipulative guidance controller 30 a generates a guided location manipulation anchor(s) 50 a, guided motion manipulation anchor(s) 51 a and/or guided positioning manipulation anchor(s) 52 a by analyzing a correlation of the endoscopic view 11 a of the anatomical structure with a knowledge base 40 including image(s) 41 of the anatomical structure, anatomical model(s) 42 of the anatomical structure, an image compilation 42 of the anatomical structure, salient feature information 43 of the anatomical structure and/or a planned navigation 44 of endoscope 10 a relative to the anatomical structure. As will be further described in the present disclosure, manipulative guidance controller 30 a derives the guided manipulation anchor(s) based on a degree of correlation of the endoscopic view 11 a of the anatomical structure with the knowledge base 40.

Manipulative guidance controller 30 a controls a display of guided location manipulation anchor(s) 50 a, guided motion manipulation anchor(s) 51 a and/or guided positioning manipulation anchor(s) 52 a within a display of endoscopic view 11 a of an anatomical structure on monitor 70 via display controller 60 a as known in the art of the present disclosure or hereinafter conceived.

In a second exemplary embodiment as shown in FIG. 2B, an endoscopic viewing controller 20 b generates an endoscopic view 11 a of an anatomical structure from an endoscope 10 a as known in the art of the present disclosure. Endoscopic viewing controller 20 b employs a guidance planner 21 for generating a planned view of the anatomical structure via a volume scan of an anatomical region as known in the art of the present disclosure or hereinafter conceived, and an image guide 22 for controlling a display of an endoscopic view 11 b of an anatomical structure on monitor 70 via a display controller 60 b as known in the art of the present disclosure or hereinafter conceived. The display of endoscopic view 11 b may be adjacent to or overlaid upon a display of the volume scan of the anatomical region.

A manipulative guidance controller 30 b receives endoscopic view 11 a of the anatomical structure from endoscopic viewing controller 20 b as shown or alternatively ascertains endoscopic view 11 a of the anatomical structure from a tracking of endoscope 10 a relative to the volume scan of the anatomical region. Manipulative guidance controller 30 b generates a guided location manipulation anchor(s) 50 b, guided motion manipulation anchor(s) 51 b and/or guided positioning manipulation anchor(s) 52 b by analyzing a correlation of the endoscopic view 11 a of the anatomical structure with a knowledge base 40 including image(s) 41 of the anatomical structure, anatomical model(s) 42 of the anatomical structure, an image compilation 42 of the anatomical structure, salient feature information 43 of the anatomical structure and/or a planned navigation 44 of endoscope 10 a relative to the anatomical structure. As will be further described in the present disclosure, manipulative guidance controller 30 a derives the guided manipulation anchor(s) based on a degree of correlation of the endoscopic view 11 a of the anatomical structure with the knowledge base 40. Manipulative guidance controller 30 b communicates the guided manipulation anchor(s) to endoscopic imaging controller 20 b, whereby image guide 22 controls a display of guided location manipulation anchor(s) 50 b, guided motion manipulation anchor(s) 51 b and/or guided positioning manipulation anchor(s) 52 b within a display of endoscopic view 11 b of an anatomical structure on monitor 70 via display controller 60 b as known in the art of the present disclosure or hereinafter conceived.

In a third exemplary embodiment as shown in FIG. 2C, an endoscopic viewing controller 20 c generates an endoscopic view 11 a of an anatomical structure from an endoscope 10 a as known in the art of the present disclosure. Endoscopic viewing controller 20 c employs a guidance planner 21 for generating a planned view of the anatomical structure via a volume scan of an anatomical region as known in the art of the present disclosure or hereinafter conceived, and an image guide 22 b for controlling a communication of endoscopic view 11 a to manipulative guidance controller 30 c.

Manipulative guidance controller 30 c receives endoscopic view 11 a of the anatomical structure from endoscopic viewing controller 20 c as shown and generates a guided location manipulation anchor(s) 50 c, guided motion manipulation anchor(s) 51 c and/or guided positioning manipulation anchor(s) 52 c by analyzing a correlation of the endoscopic view 11 a of the anatomical structure with a knowledge base 40 including image(s) 41 of the anatomical structure, anatomical model(s) 42 of the anatomical structure, an image compilation 42 of the anatomical structure, salient feature information 43 of the anatomical structure and/or a planned navigation 44 of endoscope 10 a relative to the anatomical structure. As will be further described in the present disclosure, manipulative guidance controller 30 c derives the guided manipulation anchor(s) based on a degree of correlation of the endoscopic view 11 a of the anatomical structure with the knowledge base 40.

Manipulative guidance controller 30 c communicates an endoscopic view 11 c of an anatomical structure with overlaid guide manipulation anchors to a display controller 60 c for display on monitor 70 via a display controller 60 a as known in the art of the present disclosure or hereinafter conceived. The display of endoscopic view 11 c may be adjacent to or overlaid upon a display of the volume scan of the anatomical region.

To further facilitate an understanding of the present disclosure, the following description of FIG. 3 teaches respective exemplary embodiments of a manipulative endoscopic guidance method in accordance with the present disclosure. From the description of FIG. 3 , those having ordinary skill in the art of the present disclosure will appreciate how to apply the present disclosure to make and use additional embodiments of manipulative endoscopic guidance methods in accordance with the present disclosure.

Referring to FIG. 3 , a manipulative endoscopic method of the present disclosure during an endoscopic procedure involves a manipulative guidance controller of the present disclosure executing an endoscopic view correlation analysis S100 of unmanipulated anatomical structure AS as an endoscope 10 is focused or navigated within an anatomical region AR and a guided tool manipulation anchor generation S110 of display of guided manipulative anchor(s) on the endoscope view 11 of an anatomical structure AS as needed.

These stages S100 and S110 are continuously repeated as necessary by the manipulative guidance controller, depending on the goal of the guidance, where the anatomical structure is altered in accordance with the guided manipulative anchor(s). For example, if the goal is to reconstruct a large field of view of the anatomical structure AS, then the manipulative guidance controller will repeatedly show manipulation suggestions until it acquires enough views to stitch together a full view of the anatomical structure AS

In practice of stages S100 and S110, the manipulative guidance controller first analyzes the present instantaneous endoscope view 11. If the manipulative guidance controller does not have a complete understanding of what is in the endoscopic view 11 (i.e., an unknow view 111), then the manipulative guidance controller generates guided manipulation anchor(s) and overlays the anchor(s) onto the endoscope view 11, so that the clinician knows where to perform the guided manipulation. The clinician may carry out the indicated guided manipulation, thus putting the anatomical structure AS in the view to a known or recognizable state. The state of knowing may be visual, tactile (through force sensing), or other measures engaged by the clinician in the act of manipulating the anatomical structure AS. The manipulative guidance controller then analyzes and incorporates the new information revealed into knowledge base 40, which the manipulative guidance controller subsequently draws upon to guide the clinician later in the procedure.

An example of knowledge base 40 is a preoperative volume scan (e.g., a CT scan or a MRI can), which captures a state of the anatomical structure AS at a point of time before the procedure. The mapping between a preoperative volume scan and an endoscope image may not be fully known at the start of surgery for a variety of reasons. For example, the images are acquired using different modalities, so the images capture similar information in different ways, which have to be resolved. By further example, the state of the anatomical region AR changes between preoperative and intraoperative states via processes such as deformation or body position, which have to be resolved. Intraoperative view in the endoscope does not capture the full anatomical structure AS under consideration and may be ambiguous as to a relation to the preoperative volume scan, in which case more views must be acquired intraoperatively to match endoscopic images to the preoperative counterpart.

Knowledge base 40 may also be sourced from past data. The data may be a statistical compilation or learned using machine learning techniques. The data may include preoperative images, intraoperative images used in surgery, or even non-image data such as forces, task sequences, etc. In other words, information about a patient may be seeded by information sources that come from somewhere other than the patient, and as the surgery progresses the generic information may be tuned to better match the patient.

If the manipulative guidance controller starts with a partial mapping between a preoperative knowledge base 40 and endoscopic view 11, then the manipulative guidance controller may guide the clinician on how to manipulate known anatomical structure AS to expose those parts that yet unknown are unknown to the manipulative guidance controller. This may be of particular value if the clinician is looking for a part of the anatomical structure AS that is not currently in view. As an example, say neither the manipulative guidance controller nor the clinician knows where a major blood vessel is located within anatomical region AR, but based on a knowledge base 40 and current endoscopic view 11, the manipulative guidance controller may infer where the blood vessel may be in anatomical region AR. Then the manipulative guidance controller may guide the clinician on manipulations of the anatomical structure AS that may reveal the hidden vessel. Location markings and motion directives of guided manipulations of anatomical structure AS may be suggested by the manipulative guidance controller in order to reveal visual, tactile, and other forms of anatomical structure AS properties, depending on the sensing elements utilized by manipulative guidance controller.

This manipulative endoscopic guidance method preferably takes place with minimal disruption to the clinician's workflow, i.e., the clinician must be able to perform the procedure naturally without being distracted to respond to the manipulative guidance controller. The manipulative guidance controller also must be able to provide manipulation guidance judiciously by interpreting the state of the procedure or clinician needs.

Still referring to FIG. 3 , in the previous embodiment, the manipulative guidance controller does not have complete understanding (e.g., a mapping from live endoscopy to preoperative knowledge base 40), but has enough understanding to guide the clinician on how to manipulate anatomical structure AS to gain a better mapping. In this embodiment, the manipulative guidance controller already recognizes what the manipulative guidance controller sees in the view (e.g., a known view 112), and may thus help guide the clinician on how to manipulate the anatomical structure AS in order for the clinician to recognize what they see.

For example, as shown in stage S110, an endoscopic view 11 d of a liver is at an oblique angle, which makes it difficult for the clinician to recognize the liver. This is represented by the oblique shaded square. The manipulative guidance controller understands that a critical vessel or tumor is in that location, and instructs the clinician on where and how to grasp the organ so that stretch the liver whereby the clinician may find see the critical vessel/tumor in an endoscopic view 11 e. In this view, the liver is now at an upright facing angle view, making it easier and faster for a clinician to interpret and find clinically relevant features.

Alternatively, the manipulative guidance controller may see the liver at such an oblique angle in endoscopic view 11 d of the liver that the manipulative guidance controller cannot precisely recognize the liver or register the liver to knowledge base 40. So the manipulative guidance controller may at least determine the angle that the liver needs to be facing to be more visually recognizable, so it computes a location on the liver for the clinician to grasp and a direction for the clinician to pull. When the clinician proceeds with this guidance, the result is a view that the manipulative guidance controller may recognize with high confidence. This in turn allows the manipulative guidance controller to fuse different information sources into the same view to help clinicians find things further.

In practice, the manipulative guidance controller may need to know a rough location of the anatomical structure AS within the anatomical region AR in order to suggest to the clinician how to manipulate the anatomical structure AS. For example, for endoscopic view 11 may be recognizable by the manipulative guidance controller but insufficient for 3D registration required for 3D overlays, the manipulative guidance controller may implement a base view classifier (e.g., a convolutional neural network) may be trained as known in the art of the present disclosure to communicate, such as, for example, “This 2D view requires manipulation of anatomical structure AS roughly at this mark and/or in this direction.”

Still referring to FIG. 3 , in another exemplary embodiment, the manipulative guidance controller may rely on a judgment of the clinician. More particularly, in a guided view 113 of stage S110, the manipulative guidance controller shows guide manipulation anchors 52 on a preoperative model 12, and the clinician follows that guide in an endoscopic view 11, which has the effect of correlating the preoperative model 12 and endoscopic view 11. While a single such instance may be insufficient to generate a complete mapping or registration between the preoperative model 12 and endoscopic view 11, multiple, carefully planned instances may generate enough corresponding information. Alternatively, a preoperative image be whereby the clinician looks at a raw view of the endoscopic view 11, uses clinical judgement to find the corresponding anchor(s) on the anatomical structure, and then manipulates those anchor(s) to register the endoscopic view 11 to the preoperative image.

As previously described in the present disclosure, the manipulative guidance controller generates guided manipulation anchor(s) for guiding manipulation of anatomical structure AS manipulation by examining the anatomical structure AS and correlating it to a knowledge base 40. The assumption is that there is an overlap of information, but the connection between endoscopic view 11 and the knowledge base 40 may be incomplete. The manipulative guidance controller then uses what it knows to guide the clinician to reveal what it does not know, to improve its knowledge base 40.

In this case, the manipulative guidance controller has partial information.

In the case where the manipulative guidance controller has full information in one modality (e.g., endoscopy and preoperative images), then the manipulative guidance controller may use that knowledge to generate guided manipulation anchor(s) for anatomical structure AS manipulation guidance in order to gain further data of a different modality (e.g., force).

As previously described in the present disclosure, knowledge base 40 may have numerous and various sources of information that may be used to generate a new set of guided manipulation anchor(s). Examples of these sources includes, but are not limited to, preoperative and intraoperative images, information on anatomical structure non-image in nature, statistical compilations of images from past procedures, and knowledge that is learned from past procedures.

The anchors may also be seeded by the clinician using an interactive virtual marking system. In this embodiment, the manipulative guidance controller does not have complete information about the anatomical region, but it may have some loosely coupled preoperative information. The clinician may then use an instrument to label some features they see on the anatomical structure AS, and the virtual labels may be incorporated into the knowledge base 40, allowing the manipulative guidance controller to provide image and manipulation guidance later on in the surgery.

For example, the manipulative guidance controller may incorporate interactive labeling system as known in the art of the present disclosure or hereinafter conceived whereby the clinician uses an instrument to virtually mark and label the anatomical structure AS in the endoscopic view 11 (e.g., a marking via stars indicating locations of a tumor margin, an airway and a vessel). The manipulative guidance controller may then combine this knowledge in real time with its existing knowledge base 40 to provide further anatomical structure manipulation guidance.

In practice, the manipulative guidance controller may generate guided manipulation anchors for the clinician without having semantic information as well. In an embodiment, the manipulative guidance controller detects salient image patterns of interest. Examples of salient patterns include, but are not limited to, high texture areas, areas of common texture or appearance, areas of high contrast compared to its neighbors, patterns that have not been seen before, patterns that have been seen before, patterns that have been seen repeatedly, areas adjacent to areas that are semantically identifiable, and so on. More particularly, the trackable patterns in the anatomical structure AS may be found using a well-known algorithm (e.g., SURF) and the manipulative guidance controller finds a persistent label for these areas. These labels may be refined further to decide on which are to become guided manipulation anchors, as mentioned above.

Still referring to FIG. 3 , the practice of stages S100 and S110 is an endoscopic procedure includes an initial planning phase involving a pre-operative or an intra-operative volume scan of anatomical structure AS within anatomical region AR. From the volume scan, the clinician utilizes endoscopic viewing controller 20 or other controller as known in the art of the present disclosure to identify one or more target view(s) within the volume scan of anatomical structure AS for performing a diagnosis, a treatment or a surgery. Depending on the state of the anatomical structure and the goal of the endoscopic procedure, an entirety of the target view may or may not be viewable by an endoscope 10 when endoscope 10 is positioned within a patient.

More particularly, a planning interface as known in the art of the present disclosure may be used for viewing and annotating 2D and 3D data for the purpose of ascertaining target view(s) of the anatomical structure during the procedure. This may be done intra-operatively in the endoscope view involving a fusion of an endoscopic image and volume image, because such an endoscope plan may be done on volumetric image of patient anatomy considering geometries of anatomy and kinematics of the endoscope and other constraints in the clinician preferences. For example, a trocar position relative to the target organ (between the ribs) and geometry and motions of the endoscope (for straight endoscopes it will be the set of positions govern by rotation about the trocar entry point).

The planning phase further involves updating knowledge base 40 of manipulative guidance controller 30 with volume scan of the anatomical structure AS, a planned path, salient feature(s) of the anatomical structure and a task sequence whereby, prior to or concurrently with endoscope 10 being navigated within the anatomical region manipulative guide controller 30 may (1) ascertain a degree to which a target view will be visible to endoscope 10 and/or (2) ascertain one or more recognizable poses of a target view.

After the planning phase, the endoscopic procedure includes a navigation phase of endoscope 10 within the patient P whereby manipulative guidance controller 30 is correlating, to a highest degree possible, the endoscopic view of the anatomical region as the endoscope 10 is being navigated to a position relative to a target view.

One correlation embodiment encompasses manipulative guidance controller 30 attempting to ascertain, to a highest degree possible, the endoscopic view matching the target view within the volume scan stored within the knowledge base 40 as the endoscope 10 is being navigated to a position relative to a target view. Once positioned, if manipulative guidance controller 30 recognizes the endoscopic view matching the target view within the volume scan stored within the knowledge base 40, then manipulative guidance controller 30 will either generate guided manipulation anchors to expose invisible aspects of the anatomical structure or generate guided manipulation anchors to adjust a view of visible aspects of the anatomical structure.

Alternatively, a model of the anatomical structure or a compilation of images may be used in lieu of the volume scan.

Another correlation embodiment encompasses an attempted tracking, to the highest degree possible, of the endoscope navigated to a position relative to a target view. Once manipulative guidance controller 30 determines the endoscope reaches such a position per the planned path or tasks sequence in the knowledge base, if manipulative guidance controller 30 recognizes the endoscopic view matching the target view within the volume scan stored within the knowledge base 40, then manipulative guidance controller 30 will either then manipulative guidance controller 30 will either generate guided manipulation anchors to expose invisible aspects of the anatomical structure or generate guided manipulation anchors to adjust a view of visible aspects of the anatomical structure.

Again, alternatively, a model of the anatomical structure or a compilation of images may be used in lieu of the volume scan.

Another correlation embodiment encompasses an attempted identification, to the highest degree possible, of salient features of the anatomical structure adjacent the target view. Once manipulative guidance controller 30 determines the endoscope reaches such a position per the planned path or tasks sequence in the knowledge base, if manipulative guidance controller 30 recognizes the endoscopic view showing the salient features of the anatomical structure adjacent the target view within the volume scan stored within the knowledge base 40, then manipulative guidance controller 30 will either then manipulative guidance controller 30 will either generate guided manipulation anchors to expose invisible aspects of the anatomical structure or generate guided manipulation anchors to adjust a view of visible aspects of the anatomical structure.

Again, alternatively, a model of the anatomical structure or a compilation of images may be used in lieu of the volume scan.

To facilitate a further understanding of the various inventions of the present disclosure, the following description of FIGS. 4 and 5 respectively teaches exemplary embodiments of a manipulative endoscopic guide system and a manipulative guidance controller of the present disclosure. From this description, those having ordinary skill in the art will appreciate how to apply various aspects of the present disclosure for making and using additional embodiments of manipulative endoscopic guide devices and manipulative guidance controllers of the present disclosure.

Referring to FIG. 4 , in one exemplary embodiment, a manipulative endoscopic guide system of the present disclosure is a workstation 200 employing a monitor 201, a keyboard 202 and a computer 203 as known in the art of the present disclosure. An endoscope 210 is in communication, wired or wireless, with workstation 200 as known in the art of the present disclosure or hereinafter received. An optional robot 220 for performing guided manipulations may also be communication, wired or wireless, with workstation 200.

A control network 250 of a display controller 260 as known in the art of the present disclosure or hereinafter conceived, a robot controller 270 as known in the art of the present disclosure or hereinafter conceived, an endoscopic imaging controller 280 as previously described in the present disclosure and a manipulative guidance controller 290 as previously described in the present disclosure are installed in workstation 200. Additional control networks 250 may also be installed in a server (not shown), a mobile device (e.g., a tablet 230 as shown) and an augmented reality device (e.g., a head mounted display 240 as shown).

Still referring to FIG. 4 , in practice, the specific mechanism involved to effect guided manipulation may serve as a basis on a determination on how the guidance is communicated to the clinician. For example, manual or robotic instruments (e.g., robot 220) may be used in an equivalent manner to grasp tissue based on guidance.

More particularly, the motion may assist such that it is semi-automatic. For example, with robotic tools, the clinician only needs to bring an end effector to the general region of the guided manipulative anchor, and then the robot can automatically perform the remainder of the grasp and manipulation as known in the art of the present disclosure.

In one exemplary embodiment, magnetic devices as known in the art of the present disclosure or hereinafter conceived may be used to effect guided manipulation. For example, Levita® Magnetics commercially provides a magnetic surgical platform including a magnetic module that sits on top of the patient's abdomen and a ferromagnetic module clip attached to the portion of the tissue to be pulled. This clip is inserted through surgical ports and deployed by clamping to the tissue to be held. The magnetic module is then placed on top of the patient's abdomen, attracting the ferromagnetic module towards the magnetic module the process, thereby holding the tissue suspended to expose other tissue.

In practice, where there are multiple methods to grasp and move anatomical structure(s) (e.g., tissue), guided manipulation anchors may be shown in a way that distinguishes which type of method(s) should be used for a given grasp instance. This is also a way manipulative guidance controller 290 may predict a result of the grasp maneuver, based on the grasping mechanism used. Manipulative guidance controller 290 further remind the clinician that detachable clips are in place, and may instruct the clinician on how to move the magnetic module to achieve a grasp maneuver.

Referring to FIG. 5 , a manipulative guidance controller 290 a is an exemplary embodiment of manipulative guidance controller 290 (FIG. 4 ) including one or more processor(s) 291, memory 292, a user interface 293, a network interface 294, and a storage 295 interconnected via one or more system buses 296.

Each processor 291 may be any hardware device, as known in the art of the present disclosure or hereinafter conceived, capable of executing instructions stored in memory 292 or storage or otherwise processing data. In a non-limiting example, the processor(s) 291 may include a microprocessor, field programmable gate array (FPGA), application-specific integrated circuit (ASIC), or other similar devices.

The memory 292 may include various memories, as known in the art of the present disclosure or hereinafter conceived, including, but not limited to, L1, L2, or L3 cache or system memory. In a non-limiting example, the memory 292 may include static random access memory (SRAM), dynamic RAM (DRAM), flash memory, read only memory (ROM), or other similar memory devices.

The user interface 293 may include one or more devices, as known in the art of the present disclosure or hereinafter conceived, for enabling communication with a user such as an administrator. In a non-limiting example, the user interface may include a command line interface or graphical user interface that may be presented to a remote terminal via the network interface 294.

The network interface 294 may include one or more devices, as known in the art of the present disclosure or hereinafter conceived, for enabling communication with other hardware devices. In a non-limiting example, the network interface 294 may include a network interface card (NIC) configured to communicate according to the Ethernet protocol. Additionally, the network interface 294 may implement a TCP/IP stack for communication according to the TCP/IP protocols. Various alternative or additional hardware or configurations for the network interface 294 will be apparent.

The storage 295 may include one or more machine-readable storage media, as known in the art of the present disclosure or hereinafter conceived, including, but not limited to, read-only memory (ROM), random-access memory (RAM), magnetic disk storage media, optical storage media, flash-memory devices, or similar storage media. In various non-limiting embodiments, the storage 295 may store instructions for execution by the processor(s) 291 or data upon with the processor(s) 291 may operate. For example, the storage 295 may store a base operating system for controlling various basic operations of the hardware. The storage 295 also stores application modules in the form of executable software/firmware for implementing the various functions of the manipulative guidance controller 290 a as previously described in the present disclosure including, but not limited to, a view correlator 298 a and an anchor generator 298 b. Storage S295 also stores a knowledge base 299 in accordance with the various embodiments of knowledge bases as previously described in the present disclosure.

FIG. 6 illustrate a flowchart 300 representative of a manipulative guidance method of the present discloses executable by view correlator 298 a and anchor generator 298 b of FIG. 5 .

Referring to FIG. 6 , a stage S302 of flowchart 300 involves view correlator 298 a receiving or identifying an endoscopic view of an anatomical structure as previously described in the present disclosure, and a stage S304 of flowchart 300 involves view correlator 298 a performing an endoscopic view correlation analysis of an endoscopic view of an anatomical structure as previously described in the present disclosure. More particularly, view correlator 298 a relates, to the best degree possible, the endoscope view to a knowledge base of images(s), model(s) and/or procedure detail(s) of the endoscopic procedure. For example, view correlator 298 determines, to the best degree possible, a position of endoscopic view of an anatomical structure within a volume scan of an anatomical region or on an anatomical model via registration techniques as known in the art of the present disclosure or from a tracking of the endoscope indicative of a camera positioning of the endoscope relative to the anatomical region.

Still referring to FIG. 6 , view correlator 298 a will remain in a loop of stages S302 and S304, and upon a trigger of an endoscopic view manipulation of stage S306 of flowchart 300, a stage S308 of flowchart 300 involves anchor generator 298 b generating guided manipulation anchor(s) previously described in the present disclosure, and a stage S310 of flowchart of flowchart 300 involves anchor generator 298 b updating the knowledge base based on a manipulation of the anatomical structure.

Referring to FIGS. 1-6 , those having ordinary skill in the art of the present disclosure will appreciate numerous benefits of the present disclosure including, but not limited to guidance suggestions for a clinician (e.g., a radiologist, a therapist or a surgeon) on how to manually or robotically manipulate anatomical structure(s) (e.g., tissue, bone, nerves and blood vessels) in an endoscopic view that may (1) reveal hidden anatomical structure(s) within the endoscopic view and (2) position and/or orient tissue to facilitate an analysis of the anatomical structure(s) within the endoscopic view.

Further, as one having ordinary skill in the art will appreciate in view of the teachings provided herein, structures, elements, components, etc. described in the present disclosure/specification and/or depicted in the Figures may be implemented in various combinations of hardware and software, and provide functions which may be combined in a single element or multiple elements. For example, the functions of the various structures, elements, components, etc. shown/illustrated/depicted in the Figures can be provided through the use of dedicated hardware as well as hardware capable of executing software in association with appropriate software for added functionality. When provided by a processor, the functions can be provided by a single dedicated processor, by a single shared processor, or by a plurality of individual processors, some of which can be shared and/or multiplexed. Moreover, explicit use of the term “processor” or “controller” should not be construed to refer exclusively to hardware capable of executing software, and can implicitly include, without limitation, digital signal processor (“DSP”) hardware, memory (e.g., read only memory (“ROM”) for storing software, random access memory (“RAM”), non-volatile storage, etc.) and virtually any means and/or machine (including hardware, software, firmware, combinations thereof, etc.) which is capable of (and/or configurable) to perform and/or control a process.

Moreover, all statements herein reciting principles, aspects, and embodiments of the invention, as well as specific examples thereof, are intended to encompass both structural and functional equivalents thereof. Additionally, it is intended that such equivalents include both currently known equivalents as well as equivalents developed in the future (e.g., any elements developed that can perform the same or substantially similar function, regardless of structure). Thus, for example, it will be appreciated by one having ordinary skill in the art in view of the teachings provided herein that any block diagrams presented herein can represent conceptual views of illustrative system components and/or circuitry embodying the principles of the invention. Similarly, one having ordinary skill in the art should appreciate in view of the teachings provided herein that any flow charts, flow diagrams and the like can represent various processes which can be substantially represented in computer readable storage media and so executed by a computer, processor or other device with processing capabilities, whether or not such computer or processor is explicitly shown.

The terms “signal”, “data” and “command” as used in the present disclosure broadly encompasses all forms of a detectable physical quantity or impulse (e.g., voltage, current, or magnetic field strength) as understood in the art of the present disclosure and as exemplary described in the present disclosure for transmitting information and/or instructions in support of applying various inventive principles of the present disclosure as subsequently described in the present disclosure. Signal/data/command communication between various components of the present disclosure may involve any communication method as known in the art of the present disclosure including, but not limited to, signal/data/command transmission/reception over any type of wired or wireless datalink and a reading of signal/data/commands uploaded to a computer-usable/computer readable storage medium.

Having described preferred and exemplary embodiments of the various and numerous inventions of the present disclosure (which embodiments are intended to be illustrative and not limiting), it is noted that modifications and variations can be made by persons skilled in the art in light of the teachings provided herein, including the Figures. It is therefore to be understood that changes can be made in/to the preferred and exemplary embodiments of the present disclosure which are within the scope of the embodiments disclosed herein.

Moreover, it is contemplated that corresponding and/or related systems incorporating and/or implementing the device/system or such as may be used/implemented in/with a device in accordance with the present disclosure are also contemplated and considered to be within the scope of the present disclosure. Further, corresponding and/or related method for manufacturing and/or using a device and/or system in accordance with the present disclosure are also contemplated and considered to be within the scope of the present disclosure. 

1. A manipulative endoscopic guidance device, comprising: an endoscopic viewing controller configured to control a display of an endoscopic view of an anatomical structure; and a manipulative guidance controller configured to control a display of at least one guided manipulation anchor within the display of the endoscopic view of the anatomical structure, the one or each guided manipulation anchor being representative of at least one of a location marking and a motion directive of a guided manipulation of the anatomical structure.
 2. The manipulative endoscopic guidance device of claim 1, wherein the manipulative guidance controller being configured to control the display of the at least one guided manipulation anchor within the display of the endoscopic view of the anatomical structure includes: the manipulative guidance controller configured to analysis a correlation of the endoscopic view of the anatomical structure with a baseline image of the anatomical structure; and the manipulative guidance controller configured to derive the at least one guided manipulation anchor based on a degree of correlation of the endoscopic view of the anatomical structure with the baseline image of the anatomical structure.
 3. The manipulative endoscopic guidance device of claim 1, wherein the manipulative guidance controller being configured to control the display of the at least one guided manipulation anchor within the display of the endoscopic view of the anatomical structure includes: the manipulative guidance controller configured to analysis a correlation of the endoscopic view of the anatomical structure with an anatomical structure model; and the manipulative guidance controller configured to derive the at least one guided manipulation anchor based on a degree of correlation of the endoscopic view of the anatomical structure with the anatomical structure model.
 4. The manipulative endoscopic guidance device of claim 1, wherein the manipulative guidance controller being configured to control the display of the at least one guided manipulation anchor within the display of the endoscopic view of the anatomical structure includes: the manipulative guidance controller configured to analysis a correlation of the endoscopic view of the anatomical structure with an anatomical structure image compilation; and the manipulative guidance controller configured to derive the at least one guided manipulation anchor based on a degree of correlation of the endoscopic view of the anatomical structure with the anatomical structure image compilation.
 5. The manipulative endoscopic guidance device of claim 1, wherein the manipulative guidance controller being configured to control the display of the at least one guided manipulation anchor within the display of the endoscopic view of the anatomical structure includes: the manipulative guidance controller configured to analysis a correlation of the endoscopic view of the anatomical structure with at least one salient feature of the anatomical structure; and the manipulative guidance controller configured to derive the at least one guided manipulation anchor based on a degree of correlation of the endoscopic view of the anatomical structure with the at least one salient feature of the anatomical structure.
 6. The manipulative endoscopic guidance device of claim 1, wherein the manipulative guidance controller being configured to control the display of the at least one guided manipulation anchor within the display of the endoscopic view of the anatomical structure includes: the manipulative guidance controller configured to analysis a correlation of the endoscopic view of the anatomical structure with an endoscopic procedure associated with the anatomical structure; and the manipulative guidance controller configured to derive the at least one guided manipulation anchor based on a degree of correlation of the endoscopic view of the anatomical structure of the anatomical structure with the endoscopic procedure.
 7. The manipulative endoscopic guidance device of claim 1, wherein the manipulative guidance controller is further configured to control a command of a robot to perform at least one guided manipulation of the anatomical structure in accordance with the least one guided manipulation anchor.
 8. The manipulative endoscopic guidance device of claim 1, wherein the endoscopic viewing controller and the manipulative guidance controller are at least partially integrated.
 9. A manipulative guidance controller, comprising: a non-transitory machine-readable storage medium encoded with instructions for execution by at least one processor, the non-transitory machine-readable storage medium including the instructions to: receive an endoscopic view of the anatomical structure; and control a display of at least one guided manipulation anchor within the endoscopic view of the anatomical structure, the one or each guided manipulation anchor being representative of at least one of a location marking and a motion directive of a guided manipulation of the anatomical structure.
 10. The manipulative guidance controller of claim 9, wherein instructions to control the display of the at least one guided manipulation anchor within the endoscopic view of the anatomical structure includes instructions to: analysis a correlation of the endoscopic view of the anatomical structure with a baseline image illustrative of the anatomical structure; and derive the at least one guided manipulation anchor based on a degree of correlation of the endoscopic view of the anatomical structure with the baseline image.
 11. The manipulative guidance controller of claim 9, wherein instructions to control the display of the at least one guided manipulation anchor within the endoscopic view of the anatomical structure includes instructions to: analysis a correlation of the endoscopic view of the anatomical structure with an anatomical structure model; and derive the at least one guided manipulation anchor based on a degree of correlation of the endoscopic view of the anatomical structure of the anatomical structure with the anatomical structure model.
 12. The manipulative guidance controller of claim 9, wherein instructions to control the display of the at least one guided manipulation anchor within the endoscopic view of the anatomical structure includes instructions to: analysis a correlation of the endoscopic view of the anatomical structure with an anatomical structure image compilation; and derive the at least one guided manipulation anchor based on a degree of correlation of the endoscopic view of the anatomical structure with the anatomical structure image compilation.
 13. The manipulative guidance controller of claim 9, wherein instructions to control the display of the at least one guided manipulation anchor within the endoscopic view of the anatomical structure includes instructions to: analysis a correlation of the endoscopic view of the anatomical structure with at least one salient feature of the anatomical structure; and derive the at least one guided manipulation anchor based on a degree of correlation of the endoscopic view of the anatomical structure with the at least one salient feature of the anatomical structure.
 14. The manipulative guidance controller of claim 9, wherein instructions to control the display of the at least one guided manipulation anchor within the endoscopic view of the anatomical structure includes instructions to: analysis a correlation of the endoscopic view of the anatomical structure with an endoscopic procedure associated with the anatomical structure; and derive the at least one guided manipulation anchor based on a degree of correlation of the endoscopic view of the anatomical structure with the endoscopic procedure.
 15. The manipulative guidance controller of claim 9, wherein the non-transitory machine-readable storage medium further includes the instructions to: controlling a command of a robot to perform at least one guided manipulation of the anatomical structure in accordance with the least one guided manipulation anchor.
 16. A manipulative endoscopic guidance method executable by a manipulative guidance controller, the endoscopic manipulative endoscopic guidance method comprising: receiving, by the manipulative guidance controller, an endoscopic view of an anatomical structure; and controlling, by the manipulative guidance controller, a display of at least one guided manipulation anchor within the endoscopic view of the anatomical structure, the one or each guided manipulation anchor being representative of at least one of a location marking and a motion directive of a guided manipulation of the anatomical structure.
 17. The manipulative endoscopic guidance method of claim 16, wherein the controlling, by the manipulative guidance controller, of the display of the at least one guided manipulation anchor within the endoscopic view of the anatomical structure includes: analyzing, by the manipulative guidance controller, a correlation of the endoscopic view of the anatomical structure with a baseline image of the anatomical structure; and deriving, by the manipulative guidance controller, the at least one guided manipulation anchor based on a degree of correlation of the endoscopic view of the anatomical structure with the baseline image of the anatomical structure.
 18. The manipulative endoscopic guidance method of claim 16, wherein the controlling, by the manipulative guidance controller, of the display of the at least one guided manipulation anchor within the endoscopic view of the anatomical structure includes: analyzing, by the manipulative guidance controller, a correlation of the endoscopic view of the anatomical structure with at least one of an anatomical structure model and an anatomical structure image compilation; and deriving, by the manipulative guidance controller, the at least one guided manipulation anchor based on a degree of correlation of the endoscopic view of the anatomical structure with the at least of the anatomical structure model and the anatomical structure image compilation.
 19. The manipulative endoscopic guidance method of claim 16, wherein the controlling, by the manipulative guidance controller, of the display of the at least one guided manipulation anchor within the endoscopic view of the anatomical structure includes: analyzing, by the manipulative guidance controller, a correlation of the endoscopic view of the anatomical structure with at least one of a salient feature of the anatomical structure and an endoscopic procedure associated with the anatomical structure; and deriving, by the manipulative guidance controller, the at least one guided manipulation anchor based on a degree of correlation of the endoscopic view of the anatomical structure with the at least one of the salient feature and the endoscopic procedure.
 20. The manipulative endoscopic guidance method of claim 16, further comprising: controlling, by the manipulative guidance controller, a commanding of a robot to perform at least one guided manipulation of the anatomical structure in accordance with the least one guided manipulation anchor. 